Key Scientific Insights - At A Glance
- NAD+ (nicotinamide adenine dinucleotide) is a critical coenzyme for cellular energy production, DNA repair, and aging regulation
- Intracellular NAD+ levels decline with age, potentially contributing to multiple aspects of biological aging
- Our Swiss-engineered technology measures actual cellular NAD+ concentration, not just serum levels
- Essential mineral cofactors directly influence NAD+ metabolism and utilisation
- Your results create a personalised blueprint for targeted cellular optimisation
Comprehensive scientific methodology explained
NAD+ (nicotinamide adenine dinucleotide) is a fundamental coenzyme found in all living cells that plays essential roles in cellular metabolism, DNA repair, and cellular signalling. Originally discovered in 1906, NAD+ has emerged as a critical molecule in our understanding of aging biology and cellular resilience.
The importance of NAD+ extends across multiple cellular functions:
Research has consistently demonstrated that NAD+ levels decline with age across multiple tissuesâtypically decreasing by 40-60% by age 70. This decline correlates with many hallmarks of aging, including:
By measuring your intracellular NAD+ status, we provide unprecedented insight into this critical aspect of cellular health and aging.
Swiss Precision and Global Excellence
Our testing methodology represents the convergence of Swiss innovation and global scientific excellence:
Swiss Development Heritage
International Laboratory Network
This approach combines the highest standards of Swiss precision with convenient regional processing, ensuring reliable and actionable results.
Our analysis begins with a simple, non-invasive collection process:
Most commercially available NAD+ tests measure whole blood or serum levelsâproviding limited insight into actual cellular function. Our technology specifically analyses intracellular NAD+ concentration, offering several key advantages:
This distinction allows us to provide truly actionable insights about your cellular energy potential and aging status.
Our Longevity NAD+ Profile examines your intracellular NAD+ levels and essential mineral cofactors required for optimal NAD+ metabolism.
NADâș is the master co-enzyme that keeps metabolism, repair and signalling running. By quantifying the molecules inside your red blood cells, this profile shows how much cellular âcurrencyâ you have in reserveâand where the leaks may be.
NADâș ferries electrons through glycolysis, the citric-acid cycle and the mitochondrial electron-transport chain, letting your cells flip nutrients into usable ATP and switch smoothly between carbs and fats as fuel.
Why it matters: stronger day-long energy and better metabolic flexibility when you fast, train or simply power through a busy week.
As the obligatory substrate for the seven sirtuin enzymes (SIRT1-7), NADâș unlocks gene programs that refine stress resistance, protein quality-control and mitochondrial biogenesis.
Why it matters: more efficient cell housekeeping, healthier mitochondria and a molecular environment associated with slower biological ageing.
PARP enzymes draw directly on NADâș to locate and mend DNA lesions, support telomere stability and keep the genome orderly under oxidative stress.
Why it matters: fewer accumulated DNA errorsâone of the hallmarks linked to healthier ageing trajectories.
Beyond metabolism, NADâș modulates calcium flux, circadian timing and immune communication via CD38-mediated pathways and downstream inflammatory cascades.
Why it matters: steadier sleepâwake rhythms, balanced inflammatory tone and sharper inter-cellular messaging throughout your tissues.
Levels typically fall 10-15 % each decade after forty, pushed lower by lifestyle stressors and oxidative loadâbut diet, movement and targeted precursors can restore the curve.
Why it matters: knowing your exact position on that slope lets you act early, not react late.
Magnesium, zinc and selenium act as molecular spark-plugsâstabilising each NADâș molecule, powering its enzymes and shielding it from oxidative loss, so every unit of your cellular âcurrencyâ works harder and lasts longer.
Magnesium stabilises NADâș in its active form, fuels ATP transfer and sits at the core of every enzyme that both makes and spends NADâș.
Why it matters: smoother ATP production, fewer muscle or rhythm hiccups and a solid base for any NADâș-raising protocol.
Zinc shapes the structure of sirtuins and PARPs, guides DNA-repair binding sites and tempers NADâș breakdown through zinc-dependent deacetylases.
Why it matters: stronger genomic maintenance, resilient immune signalling and efficient useânot wasteâof your NADâș pool.
Woven into selenoproteins such as glutathione peroxidase, selenium shields NADâș from oxidative loss, supports thyroid-driven energy regulation and keeps mitochondrial redox reactions in balance.
Why it matters: sturdier antioxidant defences, steady metabolic rate and maximised availability of the NADâș you already have.
Our proprietary analytical algorithms translate your biomarker data into actionable longevity insights through:
Below is the systematic process we walk every client through; each phase has specific objectives and decision points:
This methodical approach ensures that interventions are based on your unique biology and verifiable through objective measurementânot generic assumptions.
Our analysis and interpretation are grounded in peer-reviewed research on NAD+ biology and aging:
â
â Authoritative review connecting NADâș decline to every recognised hallmark of ageing.
â State-of-the-art overview of NAD-regulated pathways from basic science to therapeutic angles.
â Highlights circulating/intermediate metabolites as next-gen NADâș health biomarkers.
â Validates finger-prick DBS plus LC-MS for accurate intracellular NADâș quantification.
â Clinical-lab feasibility report confirming DBS NADâș stability and throughput.
â Largest NR RCT showing sustained 2-fold erythrocyte NADâș rises without adverse events.
â Demonstrates NMN-driven NADâș gains translate to measurable VOâ-max improvement.
â Shows intracellular MgÂČâș is rate-limiting for multiple NAD-dependent enzymes.
â Comprehensive review of zinc, selenium and other trace elements modulating NADâș turnover.
â Synthesises clinical-trial evidence and outlines translational gaps for next-gen NADâș therapeutics.
As longevity science advances, we continuously integrate new research findings into our analysis framework.
Our platform evolves with cutting-edge longevity science:
Our platform is designed for continuous advancement:
This test is part of the broader P4Health platformâbuilt on our Predictive, Preventative, Personalised, and Participatory approach. We don't just analyse data; we help you act on it through a connected ecosystem of tracking tools, health journeys, and community-led support.
Our comprehensive epigenetic analysis supports various applications:
Our clinical partnership program provides specialised access to patient management tools, batch testing options, and practitioner resources for integrating epigenetic insights into clinical practice.
Enterprise solutions offer scalable testing, analytics dashboards, and group health optimisation programs for organisations prioritising employee wellbeing.
Contributing to the advancement of longevity science through anonymised population-level insights while maintaining individual privacy and data security.
This scientific overview is provided for educational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. The epigenetic analysis is designed to provide insights about biological patterns that may support general wellness. Our analysis uses TGA-registered technology (ARTG entries 297844 and 398180). Individual results may vary. Always consult with your healthcare professional regarding health concerns or before making significant changes to your health regimen.
